Sqstm1 CLIA Kit for Mouse(Mus musculus) | EIAab.comSqstm1 CLIA Kit for Mouse(Mus musculus)

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Sqstm1 (Gene name),

Sequestosome-1 (Protein name ), SQSTM_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Sqstm1(A170;STAP);

Protein name:

Sequestosome-1;

Alternative:

Ubiquitin-binding protein p62;STONE14;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homooligomer or heterooligomer; may form homotypic arrays. Interacts directly with PRKCI and PRKCZ (Probable). Interacts with EBI3, LCK, RASA1, PRKCZ, PRKCI, NR2F2, NTRK1, NTRK2, NTRK3, NBR1, MAP2K5, TRIM55 and MAPKAPK5. Interacts with the proteasome subunits PSMD4 and PSMC2. Interacts with K63-polyubiquitinated MAPT/TAU. Interacts with IKBKB through PRKCZ and PRKCI. Interacts with NGFR through TRAF6 and bridges that complex to NTRK1. Forms a complex with MAP2K5 and PRKCZ or PRKCI. Component of a ternary complex with PAWR and PRKCZ. Upon TNF-alpha stimulation, interacts with RIPK1 problably bridging IKBKB to the TNF-R1 complex composed of TNF-R1/TNFRSF1A, TRADD and RIPK1. Forms a complex with JUB/Ajuba, PRKCZ and TRAF6. Forms ternary complexes with PRKCZ and KCNAB2 or PRKCZ and GABBR3. Interacts with KCNAB1, GABRR1, GABRR2 and GABRR3. Forms an NGF-induced complex with IKBKB, PRKCI and TRAF6 (By similarity). Interacts with TRAF6 and CYLD. Identified in a complex with TRAF6 and CYLD.

Function:

Adapter protein which binds ubiquitin and may regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.

Subcellular Location:

Cytoplasm Late endosome Nucleus Sarcomere. In cardiac muscles localizes to the sarcomeric band. Localizes to late endosomes. May also localize to the nucleus.

Protein Attributes:

Sequence length:

442

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

442:

SQMLSMGFSD | EGGWLTRLLQ | TKNYDIGAAL | DTIQYSKHPP | PL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.40828

STRING:

10090.ENSMUSP00000099835

KEGG:

mmu:18412

Pfam:

PF00564

String:

Q64337

SMR:

Q64337

Uniprot:

Q64337

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ELISA Kit for Mouse Sequestosome-1

Cat.:

E10081r

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96T

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ELISA Kit for Mouse Sequestosome-1

Cat.:

E10081m

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96T

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ELISA Kit for Mouse Sequestosome-1

Cat.:

E10081h

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Looking for manual.

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96T

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CLIA Kit for Mouse Sequestosome-1

Cat.:

U10081h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Sequestosome-1

Cat.:

U10081r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Sequestosome-1

Cat.:

U10081m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Sequestosome-1

Cat.:

P10081Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Sequestosome-1

Cat.:

P10081Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Sequestosome-1

Cat.:

P10081Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse Sequestosome-1

Protein for Mouse Sequestosome-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in reponse to oxidative stress."
Ishii T. , Yanagawa T. , Kawane T. , Yuki K. , Seita J. , Yoshida H. , Bannai S.
Biochem. Biophys. Res. Commun.226:456-460(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION
strain: ddY.
tissue: Macrophage.
2.

"Murine cDNA similar to EBI3-associated protein p60 mRNA."
Morris J.C. , Long A. , Finnerty H. , Fitz L. , Towler P. , Turner K. , Wood C.R.
Submitted (1996-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: BALB/c.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: C57BL/6J.
tissue: Skin.
4.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: FVB/N.
tissue: Mammary gland.
6.

"Low micromolar levels of hydrogen peroxide and proteasome inhibitors induce the 60-kDa A170 stress protein in murine peritoneal macrophages."
Ishii T. , Yanagawa T. , Yuki K. , Kawane T. , Yoshida H. , Bannai S.
Biochem. Biophys. Res. Commun.232:33-37(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
7.

"Phosphorylation of A170 stress protein by casein kinase II-like activity in macrophages."
Yanagawa T. , Yuki K. , Yoshida H. , Bannai S. , Ishii T.
Biochem. Biophys. Res. Commun.241:157-163(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
8.

"Cloning, expression profile, and genomic organization of the mouse STAP/A170 gene."
Okazaki M. , Ito S. , Kawakita K. , Takeshita S. , Kawai S. , Makishima F. , Oda H. , Kakinuma A.
Genomics60:87-95(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
9.

"Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells."
Kuusisto E. , Suuronen T. , Salminen A.
Biochem. Biophys. Res. Commun.280:223-228(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
10.

"Activation of Nrf2 and accumulation of ubiquitinated A170 by arsenic in osteoblasts."
Aono J. , Yanagawa T. , Itoh K. , Li B. , Yoshida H. , Kumagai Y. , Yamamoto M. , Ishii T.
Biochem. Biophys. Res. Commun.305:271-277(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
11.

"The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis."
Duran A. , Serrano M. , Leitges M. , Flores J.M. , Picard S. , Brown J.P. , Moscat J. , Diaz-Meco M.T.
Dev. Cell6:303-309(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;INTERACTION WITH TRAF6;DISRUPTION PHENOTYPE
12.

"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A. , Villen J. , Beausoleil S.A. , Schwartz D. , Gygi S.P.
Mol. Cell. Proteomics3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic brain.
13.

"Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death."
Holtz W.A. , Turetzky J.M. , O'Malley K.L.
Antioxid. Redox Signal.7:639-648(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
14.

"p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death."
Bjorkoy G. , Lamark T. , Brech A. , Outzen H. , Perander M. , Overvatn A. , Stenmark H. , Johansen T.
J. Cell Biol.171:603-614(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
15.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.
16.

"Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice."
Jin W. , Chang M. , Paul E.M. , Babu G. , Lee A.J. , Reiley W. , Wright A. , Zhang M. , You J. , Sun S.C.
J. Clin. Invest.118:1858-1866(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CYLD AND TRAF6;IDENTIFICATION IN A COMPLEX WITH CYLD AND TRAF6
17.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-178; THR-269 AND THR-272;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.
19.

"Structural basis for sorting mechanism of p62 in selective autophagy."
Ichimura Y. , Kumanomidou T. , Sou Y.S. , Mizushima T. , Ezaki J. , Ueno T. , Kominami E. , Yamane T. , Tanaka K. , Komatsu M.
J. Biol. Chem.283:22847-22857(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) OF 335-344 IN COMPLEX WITH MAP1LC3B;MUTAGENESIS OF 337-ASP--ASP-339; TRP-340 AND LEU-343;INTERACTION WITH GABARAP AND GABARAPL2

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